U.S.
scientists have found that the tips of his fingers cut off in mammals,
including humans, can grow again thanks to the stem cells that are found
in the nail bed, reports RIA "Novosti" with reference to an article in
the journal Nature.
Mayumi Ito and his colleagues conducted a series of experiments on mice on the regeneration of the fingertips. They found that at the base of the nail is a small group of stem cells, through which the nail is growing. Its growth is controlled by a family of proteins Wnt, and if this control mechanism is broken - the nail will not grow.
As shown by the scientists, the same mechanism is responsible for the restoration and the fingertips. After the amputation, Wnt proteins are activated in the epithelium, which lies beneath preserved piece of the nail, and are attracted to the damaged area of the nerve cells. They start the growth of germ cells of connective tissue, which then turn into bones, tendons and muscles. Through this mechanism, the tips of the fingers in mice fully recovered within 5 weeks. If the mice were amputated too much of a finger nail from where almost nothing to do but did not start the regeneration process. In this case, the scientists managed to run it by stabilizing the base of the nail protein beta-catenin, which acts as a transmitter of signals between proteins Wnt.
Scientists believe that maybe this mechanism is also in humans, and the results will help in the development of ways to restore amputated limbs.
Mayumi Ito and his colleagues conducted a series of experiments on mice on the regeneration of the fingertips. They found that at the base of the nail is a small group of stem cells, through which the nail is growing. Its growth is controlled by a family of proteins Wnt, and if this control mechanism is broken - the nail will not grow.
As shown by the scientists, the same mechanism is responsible for the restoration and the fingertips. After the amputation, Wnt proteins are activated in the epithelium, which lies beneath preserved piece of the nail, and are attracted to the damaged area of the nerve cells. They start the growth of germ cells of connective tissue, which then turn into bones, tendons and muscles. Through this mechanism, the tips of the fingers in mice fully recovered within 5 weeks. If the mice were amputated too much of a finger nail from where almost nothing to do but did not start the regeneration process. In this case, the scientists managed to run it by stabilizing the base of the nail protein beta-catenin, which acts as a transmitter of signals between proteins Wnt.
Scientists believe that maybe this mechanism is also in humans, and the results will help in the development of ways to restore amputated limbs.
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