"So-called oncolytic viruses attack only certain types of cancer cells. Unfortunately, the cells of the same tumors may differ from each other, and this reduces the effectiveness of the virus. We
have accelerated their development by means of a mathematical model, "-
said lead author John Bell and Mads Cairn from the University of Ottawa
(Canada).
Bell, Karen, and their colleagues were trying to create a virus that can destroy the cell adenocarcinoma of the kidney. According to them, the main problem of such viruses is the variability of cancer cells - they are frequently mutated gene, resulting in a change in the structure of the shell, in which the virus outgrowths distinguishes its goal of healthy tissue.
The authors have solved this problem by developing a special mathematical model. To do this, scientists have compiled a list of genetic differences between healthy and cancerous cells of the kidneys, and identified the most "noticeable" for signs of viruses. Combining these data received biological model that can predict how mutations in the viral genome will influence cells which they infect.
As the researchers note, it has allowed them to identify the most promising "versions" of the virus and test them in mice, instead of looking for them through trial and error.
Bell, Karen, and their colleagues were trying to create a virus that can destroy the cell adenocarcinoma of the kidney. According to them, the main problem of such viruses is the variability of cancer cells - they are frequently mutated gene, resulting in a change in the structure of the shell, in which the virus outgrowths distinguishes its goal of healthy tissue.
The authors have solved this problem by developing a special mathematical model. To do this, scientists have compiled a list of genetic differences between healthy and cancerous cells of the kidneys, and identified the most "noticeable" for signs of viruses. Combining these data received biological model that can predict how mutations in the viral genome will influence cells which they infect.
As the researchers note, it has allowed them to identify the most promising "versions" of the virus and test them in mice, instead of looking for them through trial and error.
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