Scientists in Japan have found that high-calorie diet alters the intestinal microflora, which may cause cancer of the liver and gastrointestinal tract.
Naoko
Ohtani of the Cancer Institute in Tokyo (Japan) and her colleagues
found that microorganisms can indirectly contribute to the development
of cancer, watching her work in the intestine of mice during the
transition to high-calorie diet. In
these experiments, doctors noticed that rodents, overweight, suffer
more from cancer than their cousins in the control group.
Scientists intrigued by this fact, and they decided to find the cause of this by analyzing the differences in the microflora and the genomes of mice from these groups. For example, some bacteria in the intestines of rodents with overweight behaved extremely unusual - they synthesized molecules of deoxycholic acid. It belongs to bile acids required for some absorption of nutrients, including vitamins A, D and E. Typically, they are not destroyed in the gut together with the blood and the liver.
Deoxycholic acid is a carcinogen that can cause damage and mutations in the DNA. This happened with the mice - when scientists destroyed the "bad" bacteria, the incidence of tumors in the liver and intestine decreased significantly, almost reaching the values characteristic of the control group. This fact shows that the high-calorie diet can actually contribute to the development of cancer, doctors conclude.
Scientists intrigued by this fact, and they decided to find the cause of this by analyzing the differences in the microflora and the genomes of mice from these groups. For example, some bacteria in the intestines of rodents with overweight behaved extremely unusual - they synthesized molecules of deoxycholic acid. It belongs to bile acids required for some absorption of nutrients, including vitamins A, D and E. Typically, they are not destroyed in the gut together with the blood and the liver.
Deoxycholic acid is a carcinogen that can cause damage and mutations in the DNA. This happened with the mice - when scientists destroyed the "bad" bacteria, the incidence of tumors in the liver and intestine decreased significantly, almost reaching the values characteristic of the control group. This fact shows that the high-calorie diet can actually contribute to the development of cancer, doctors conclude.
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