Stem Cell Research Group at the University of California at Los Angeles (UCLA) found a surprising plasticity of embryonic endothelium. Scientists have found that the absence of a transcription factor, allows the cells to progenitors that normally produce blood stem cells and progenitor cells in the hematopoietic organs to differentiate into cardiomyocytes. The results of a two-year study were published in the journal Cell.
To determine which genes are working in the embryonic endothelium, microarray technology was used, which revealed that in the absence of Scl, one of the factors of cell differentiation, rather than genes, aimed at forming a blood stem cells are activated genes that are required for the production of cardiomyocytes. The researchers cultured embryonic yolk sac, which was absent Scl, and received by 4:00 cardiomyocytes are capable of contraction. The same potential has been detected in the endocardium Scl-deficient embryos. Scientists have tried to identify the potential to become endothelial and other related tissues such as skeletal muscle, bone or kidney, but the evidence of such plasticity could not be found.
"If you remove just one factor, Scl, the microenvironment of fetal blood vessels, usually giving rise to blood cells, begins to produce cardiomyocytes, hematopoietic making body in the" cardiogenic "body," - said Dr. Hanna Mikkola (Hanna Mikkola), one of the leading authors of the study.
These data were unexpected and extremely useful for the whole of regenerative medicine, since changing the view of the possibility of reprogramming cells. Usually, this process involves the addition of any factors to change cell "fate." But, apparently, the suppression of factors such as Scl, - a more secure way to push the cell to a different path of development.
To determine which genes are working in the embryonic endothelium, microarray technology was used, which revealed that in the absence of Scl, one of the factors of cell differentiation, rather than genes, aimed at forming a blood stem cells are activated genes that are required for the production of cardiomyocytes. The researchers cultured embryonic yolk sac, which was absent Scl, and received by 4:00 cardiomyocytes are capable of contraction. The same potential has been detected in the endocardium Scl-deficient embryos. Scientists have tried to identify the potential to become endothelial and other related tissues such as skeletal muscle, bone or kidney, but the evidence of such plasticity could not be found.
"If you remove just one factor, Scl, the microenvironment of fetal blood vessels, usually giving rise to blood cells, begins to produce cardiomyocytes, hematopoietic making body in the" cardiogenic "body," - said Dr. Hanna Mikkola (Hanna Mikkola), one of the leading authors of the study.
These data were unexpected and extremely useful for the whole of regenerative medicine, since changing the view of the possibility of reprogramming cells. Usually, this process involves the addition of any factors to change cell "fate." But, apparently, the suppression of factors such as Scl, - a more secure way to push the cell to a different path of development.
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