An international team of scientists led by Bin Zhou Xi (Xibin Zhou) and Guangya Liu Teh (Guande Liu) from the Beijing University of Chemical College (College of Chemistry, Beijing Normal University, China) has established an analogue of biological transmembrane channels. The study of transmembrane transport of substances into the cell was always challenging and exciting task, so the reproduction of this system in vitro - great scientific success.
At the core of the nanotubes are created rigid macrocyclic compounds - complex molecules of several heterocyclic bases covalently assembled into a ring diameter of 8.8 angstroms. The secret of success lies in the fact that these rings have learned to apply to the stack on each other. Stacks are fixed by hydrogen bonds and stekingovymi interactions (such as those that stabilize the DNA helix), resulting in a tube. The tubes are collected and fasten together to form a molecular sieve. The pore diameter can vary depending on the family's base macrocyclic compounds. Such complexes are similar to biological ion channels in its structure and on the basis of the transmission of substances.
The closest application of this technology is to create a molecular filter for water and other low molecular weight compounds. The researchers plan to expand the range of noise substances. In the future, with the help of these nanotubes can be designed to control the delivery of pharmaceutical compounds in the tissues and organs of the body, as well as collect various macromolecular transport systems.
At the core of the nanotubes are created rigid macrocyclic compounds - complex molecules of several heterocyclic bases covalently assembled into a ring diameter of 8.8 angstroms. The secret of success lies in the fact that these rings have learned to apply to the stack on each other. Stacks are fixed by hydrogen bonds and stekingovymi interactions (such as those that stabilize the DNA helix), resulting in a tube. The tubes are collected and fasten together to form a molecular sieve. The pore diameter can vary depending on the family's base macrocyclic compounds. Such complexes are similar to biological ion channels in its structure and on the basis of the transmission of substances.
The closest application of this technology is to create a molecular filter for water and other low molecular weight compounds. The researchers plan to expand the range of noise substances. In the future, with the help of these nanotubes can be designed to control the delivery of pharmaceutical compounds in the tissues and organs of the body, as well as collect various macromolecular transport systems.
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